Patients with small-cell lung cancer that relapses after platinum chemotherapy have few effective treatment options. A new phase 3 trial shows improved survival and symptom control with the delta ...

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The authors describe the implications of the Affordable Care Act for safety-net health systems and how hospital-based safety-net care systems are responding to health care reform.

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Whether proton-pump inhibitors are beneficial or harmful for stress ulcer prophylaxis in critically ill patients undergoing invasive ventilation is unclear. In this international, randomized trial, ...

In vitro fertilization is clearly a successful technology, although it remains experimental; the safety and efficacy of new methods and reagents can be difficult to assess. And “traditional ...

Sarcoidosis, a granulomatous disease that affects the lungs and other organs, has a variable course. Although spontaneous resolution of sarcoidosis occurs in some patients, half the patients with s ...

A 68-year-old man with type 2 diabetes presented with a 3-year history of hardening of the skin on his neck and upper back.

A 54-year-old woman with metastatic breast cancer who was receiving denosumab therapy presented with right jaw pain. An area of exposed, necrotic bone was visualized in the right mandible.

Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc ...

The discovery of HCV was a major milestone in 20th-century medicine, and the 2020 Nobel awardees represent three critical periods of research on this important virus. Their discovery led to elimina ...

Cash transfers to individuals that the U.S. government made during the Covid pandemic demonstrated how such a policy tool could help address the political–economic determinants of health.