Sarcoidosis, a granulomatous disease that affects the lungs and other organs, has a variable course. Although spontaneous resolution of sarcoidosis occurs in some patients, half the patients with s ...

In vitro fertilization is clearly a successful technology, although it remains experimental; the safety and efficacy of new methods and reagents can be difficult to assess. And “traditional ...

Explore a collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary.

The author describes pronuclear transfer, a type of mitochondrial donation, which was made available to women with mitochondrial DNA disease in a reproductive care pathway implemented in Newcastle, ...

Graft-versus-host disease remains a leading cause of complications after allogeneic stem-cell transplantation. New research evaluating the efficacy of post-transplantation cyclophosphamide plus ...

Explore the current issue of The New England Journal of Medicine (Vol. 393 No. 3).

Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying pathog ...

Endovascular thrombectomy has been shown to be safe and effective in selected patients with acute ischemic stroke due to large-vessel occlusion (LVO) up to 24 hours after symptom onset.1 In pivotal ...

NEJM uses highly rigorous editorial, peer, and statistical review processes to evaluate manuscripts for scientific accuracy, novelty, and importance.

The author describes the scientific foundations and implications of a study on variant EPO and erythrocytosis.

The discovery of HCV was a major milestone in 20th-century medicine, and the 2020 Nobel awardees represent three critical periods of research on this important virus. Their discovery led to elimina ...

Cash transfers to individuals that the U.S. government made during the Covid pandemic demonstrated how such a policy tool could help address the political–economic determinants of health.