Here we present HiC-DC, a principled method to estimate the statistical significance (P values) of chromatin interactions from Hi-C experiments. HiC-DC uses hurdle negative binomial regression account ...
We derive a first-order bias-corrected maximum likelihood estimator for the negative binomial dispersion parameter. This estimator is compared, in terms of bias and efficiency, with the maximum ...
The flowers of strawberry plants grow on very variable branched structures called inflorescences, in which each branch gives rise to 0, 1, or 2 offspring branches. We extend previous modeling of the ...
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