The Oprah Winfrey Show ran from 1986-2011. Listen to the entire episode of Kelly Ripa's Let's Talk Off Camera with Oprah Winfrey below. Read the original article on Entertainment Weekly ...

Instead, Winfrey used her final show, the 4,561st, to thank the audience that made hers the No. 1 talk show for its entire 25-year run.

Oprah Winfrey delivered so many iconic moments in the 25 years her eponymous talk show was on the air — but the media mogul admits that she doesn't miss it. Speaking with Kelly Ripa on the most ...