Multiple positions of cholesterol as it translocates through the common pathway, including the off-pathway intermediate. (a) upright ( δ) (b) tilted ( γ) (c) overtilted ( E ), the off pathway ...

Shot can act as a molecular linker between microtubules and actin during dendrite pruning, suggesting an intriguing role in non-centrosomal microtubule organization. However, the experimental evidence ...

This study is valuable for understanding how dysfunctional mitochondria contribute to vascular diseases by investigating the influence of Miro1 on smooth muscle cell proliferation and neointima ...

KLF2 activity and impaired interferon signaling contribute to HIV-1 persistence by restricting antiviral immunity in infected CD4 T cells during early infection.

This leads them to conclude that “subjective measures do not reliably measure the construct they intend to measure” and that their construct validity is threatened. Here, we argue that the main ...

This study should be of interest to the communities working on cell metabolism and on host-pathogen interactions. Viral infection begins with attachment to host surface structures such as receptors, ...

The ROOT & SHOOT project in the plant sciences has produced guidelines to help scientific societies organize conferences that are more inclusive and offer more supportive environments to all attendees ...

This study presents valuable computational findings on the neural basis of learning new motor memories and the savings using recurrent neural networks. The evidence supporting the claims of the ...

Therefore, developing fungicides with novel action mechanisms is the most effective measure to manage resistance. Quinofumelin, a novel quinoline fungicide, exhibits exceptional antifungal activity ...

A versatile computational framework realistically simulates fluorescence lifetime data in biological systems, enhancing rigor by quantifying signal variance and identifying limitations, and enabling ...

The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.

Time-resolved fluorescence resonance energy transfer reveals conformational energetics of a bacterial cyclic nucleotide-gated ion channel.