During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.

This important study demonstrates the significance of incorporating biological constraints in training neural networks to develop models that make accurate predictions under novel conditions. By ...

Fingertip tactile neurons collectively encode the skin's viscoelastic state alongside current touch, potentially enabling the brain to better interpret forces during manipulation.

Committee on Neurobiology, University of Chicago Department of Organismal Biology and Anatomy, University of Chicago The Neuroscience Institute, University of Chicago ...

This valuable study concerns a model for transgenerational epigenetic inheritance, the learned avoidance by C. elegans of the PA14 pathogenic strain of Pseudomonas aeruginosa. A recent study ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States Graduate Group in Biophysics, University of California, San Francisco, San Francisco, United ...

This important work describes results from a set of simulation and empirical studies of a set-up assessing exploratory behavior in a potentially rewarding environment that contains danger. The core ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

This is a valuable contribution to our understanding of how different cell stressors (ethanol or heat-shock) elicit unique responses at the genomic and topographical level under the regulation of ...

The structure of the human METTL3-METTL14 complex has been recently reported by two other studies (Wang et al., 2016a, 2016b).Both studies utilized a slightly different METTL3-METTL14 construct, ...