The syndrome of cardiogenic shock has been defined as the inability of the heart -- as a result of impairment of its pumping function -- to deliver sufficient blood flow to the tissues to meet ...

Next-generation sequencing has enabled precision therapeutic approaches that have improved the lives of children with rare diseases. Congenital diarrhea and enteropathies (CODEs) are associated ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Chronic spontaneous urticaria is an idiopathic syndrome defined by recurring itch, hives, or angioedema (or a combination of these symptoms) for more than 6 weeks. Remibrutinib, an oral, highly ...

Decades of strict sentencing laws, the racially motivated “War on Drugs,” and simultaneous erosion of community mental health and social services have contributed to the American public health ...

Endovascular treatment is safe and effective in acute ischemic stroke caused by large-vessel occlusion; however, its benefit for occlusion of medium or distal vessels is unclear. New research ...

Currently licensed and approved malaria subunit vaccines provide modest, short-lived protection against malaria. Immunization with live-attenuated Plasmodium falciparum malaria parasites is an ...

EBV is one of the most successful viruses, infecting over 90 percent of humans and persisting for the lifetime of the person. EBV is closely related to viruses present in Old World nonhuman ...

Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative ...

Many of the challenges we address here were evident to the pioneers of medical decision analysis of the 1950s 7 and to scholars in subsequent decades 8-11 who conducted careful and creative ...

We and others identified retinoblastoma features that suggested that the tumors originate in long- and medium-wavelength cone precursors, and we discovered features of these cone precursors that ...

This review article presents two true-life clinical vignettes that illustrate how digital health technology can aid providers caring for patients with epilepsy. Specific information that would ...